CPD Science Day | November 3 Annual offsite at Brandegee Estate
Jingyi Wang, Bart Lutterbach, Devin Ryan, Shatha AbuHammad, Yingpeng Liu, Leah Ragosta, Frank Chen, Tiffany Tsang, Breanna Zerfas, Nikki Kong, Jeevan GC, Justin Cruite, Jasmin Kruell, Katherine Donovan, Jirong, Luo, Lyn Jones, Fidel Huerta, Jonathan Tosi, Yang Yang, Henning Arlt, Yingde Zhu, John Che, Radek Nowak, Pratik Vikhe, Stephen Xie
Lyn Jones, Director, presenting to CPD
October Conference Presentations
Presenter - Justin Cruite "Cereblon Covalent Modulation through Rational Design of Histidine Targeting Chemical Probes", 5th Annual Targeted Protein Degradation Summit - Pre-Conference Bootcamp, Boston North Shore, 10/25 - 10/28
Presenter - Nikki R. Kong "Employing phenotypic assays to dissect mechanisms of molecular glue degraders", Discovery on Target - PROTACs and Molecular Glues, Boston 10/17-10/20; Panelist in interactive discussion: "Targeted Protein Degradation – Where Are We Headed?" Presenter - Pratik Vikhe "Modulation of T Helper Cells by IMiDs", Discovery on Target - Pre-conference symposium on Emerging Immune Modulation Strategies, Boston, 10/17-10/20
Team CPD | 2022 Jimmy Fund Walk October 2
Yingde Zhu, John Che, Nikki Kong & Spouse, Breanna Zerfas, Justin Cruite, Lyn Jones, Hellen Kim, Jennifer Lawrence, Jonathan Tosi & Family, Yingde Zhu, Pratik Vikhe, Jirong Luo, Huang Huang, Jingyi Wang, Kishan Mahase, Leah Ragosta, Radek Nowak, Katherine Donovan, Bart Lutterbach | Oct 2, 2022
Yingde Zhu, Yingpeng Liu, Huang Huang, John Che, Radek Nowak, Jirong Luo, Jennifer Lawrence, Bart Lutterbach, Jonathan Tosi & Family, Lyn Jones, Jingyi Wang, Leah Ragosta, Hellen Kim, Kishan Mahase, Nikki Kong, Breanna Zerfas
Yingde Zhu & spouse (below), John Che, Pratik Vikhe, Jennifer Lawrence, Hellen Kim, Devin Ryan, Breanna Zerfas, Jonathan Tosi & Family, Nikki Kong & spouse (right), Jirong Luo, Justin Cruite, Katherine Donovan, Lyn Jones, Leah Ragosta | Oct 2, 2022
CPD Cricket Game | Sept 23, 2022 Our first cricket game as we bid farewell to summer
CPD Leadership team | September 20 CPD Leadership completes leadership development training conducted by Jennifer Lawrence, Katie Ward, and Lyn Jones, PhD
Huang Huang, Radek Nowak, Jonathan Tosi, John Che, Katie Ward, Jennifer Lawrence, Breanna Zerfas, Hellen Kim, Lyn Jones, Kishan Mahase, Nikki Kong | Sept 20, 2022
August New Hires: Shatha AbuHammad - Joins the CPD as a Scientist I with our Biology Team
Shatha just finished her postdoc at DFCI, where she investigated how TFE3 fusion proteins bind RNA to drive renal cell carcinoma. Prior to that, Shatha completed her PhD work at University of Melbourne, where she identified combinational therapies to co-target CDK4 and PRMT5, which will benefit melanoma patients. Shatha also has extensive CRISPR/Cas9 base-editing and phenotypic screening experiences.
Jeevan GC - Joins the CPD as a Scientist I with our Computation Team
Jeevan came from Professor Joachim Frank Lab at Columbia University where he used MD simulation and single particle Cryo-EM to study conformational changes in Ryanodine receptors and allosteric modulation of GABAB receptor. Jeevan is an expert in MD simulations and conformational analysis.
Welcome aboard Jeevan!
July New Hires: Yang Yang - Joins the CPD as a Scientist I with our Biology Team
We are excited to welcome Yang to the CPD & Biology team! Her postdoc training was completed at MGH, where she focused on small molecule and functional genomics screens to discover new therapeutic targets in idiopathic pulmonary fibrosis. Through her PhD and postdoc training, she has extensive experience in microscopy, CRISPR/Cas9 screens, and primary cell culturing.
Jirong (Eric) Luo - Joins the CPD as a Scientist I with our Chemistry Team
We are also excited to welcome Jirong to the CPD! He received his PhD of Organic Chemistry at University of Houston (Supervisor: Jeremy A. May). He was focusing the development of enantioselective conjugate addition methodology and application to the total synthesis of Cannabinoids and Mucronatins during his PhD training.
Publication: JT Cruite, GP Dann, J Che, KD Donovan, S Ferrao, SB Ficarro, ES Fischer, NS Gray, F Huerta, NR Kong, H Liu, JA Marto, RJ Metivier, RP Nowak, BL Zerfas and LH Jones. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem. Biol. 2022, accepted. https://pubs.rsc.org/en/content/articlelanding/2022/cb/d2cb00078
Publication: LH Jones, CA Mitchell, L Loberg, M Pavlovic, M Rao, R Roberts, K Stamp, L Volak, MB Wittwer, S Pettit. Targeted protein degraders: a call for collective action to advance safety assessment. Nat. Rev. Drug Disc. 2022, 21, 401-402. https://www.nature.com/articles/d41573-022-00055-9
Presentation: Lyn Jones - Covalent Modulation of Cereblon Using Sulfonyl Exchange Chemistry. DFCI Targeted Protein Webinar Series, June 2022.
April New Hire: Jingyi Wang - Joins the CPD as a Scientist I with our Chemistry Team
We are excited to welcome Jingyi to the CPD! She worked at GSK as a medicinal chemist and developed an innovative drug-screening platform using solid-phase DNA Encoded Library technology. Before joining GSK, she received her PhD of Organic Chemistry at Boston College (Supervisor: X. Peter Zhang). During her PhD training, she developed several CoII-catalyzed asymmetric cyclization and C-H activation reactions to construct complex structures with stereoselectivities.
March New Hire: Yangchun (Frank) Chen - Joins the CPD as our Computational Biologist.
Frank’s expertise is in analysis of correlations between genomics (including expressions) and phenotypes (including cellular and patient level). He will take a deep dive into the omics datasets from both public (e.g. depmap) and proprietary (e.g. proteomics, RRM screens) sources to identify potential targets of interest.
Presentation: Lyn Jones - Targeted Covalent Inhibitors and Molecular Superglues. SMR/SCI Experimental and In Silico Approaches to Target Selection and Tractability for Drug Discovery, Francis Crick Institute, London, UK, March 2022.
Presentation: Lyn Jones - Towards the Rational Design and Development of Targeted Protein Degraders Gulf Coast Consortium, 2nd Annual Innovative Drug Discovery and Development Conference, Houston TX (virtual), May 2021.